How to Reduce Inflammation Naturally When You Have MS

🧠 Inflammation: The Root of MS Progression

Multiple sclerosis is fundamentally an inflammatory autoimmune disease. Your immune system mistakenly attacks your myelin sheath—the protective coating around your nerves—leading to symptoms like:

  • Fatigue
  • Muscle weakness or spasticity
  • Brain fog
  • Tingling or numbness
  • Vision problems

Even during remission, low-grade chronic inflammation may continue to damage your nervous system silently. That’s why calming inflammation isn’t just about preventing flares—it’s about preserving long-term function.

Looking for supplements for people with MS? Click here.

🔥 What Triggers Inflammation in MS?

MS inflammation is influenced by several factors:

  • Autoimmune immune dysregulation
  • Leaky gut and microbiome imbalance
  • Poor sleep and chronic stress
  • Nutrient deficiencies (e.g., vitamin D, omega-3s)
  • Environmental toxins and oxidative stress
  • Pro-inflammatory diets (refined carbs, seed oils, processed meats)

The good news? Many of these triggers are modifiable through daily habits and targeted supplementation.

🍎 Step 1: Eat an Anti-Inflammatory MS Diet

Food is your foundation. Here’s how to shift your plate toward anti-inflammatory power.

✅ Focus on:

  • Leafy greens and colorful vegetables (high in antioxidants)
  • Berries (rich in polyphenols and flavonoids)
  • Wild fatty fish (salmon, sardines, mackerel) for omega-3s
  • Olive oil and avocados for healthy fats
  • Herbs and spices like turmeric, ginger, rosemary
  • Fermented foods (sauerkraut, kefir, miso) for gut health
  • Gluten-free whole grains (quinoa, buckwheat, brown rice) if tolerated

❌ Avoid or minimize:

  • Ultra-processed foods
  • Added sugars and sweetened drinks
  • Gluten and dairy (common triggers for many with MS)
  • Industrial seed oils (canola, soy, corn, sunflower)
  • Fried foods and fast food

🥗 Try following a modified Mediterranean, Wahls Protocol, or Autoimmune Paleo (AIP) framework.

Looking for supplements for people with MS? Click here.

💊 Step 2: Use Targeted Anti-Inflammatory Supplements

Certain supplements have shown promise for calming inflammation in MS. Here are the top science-backed choices:

1. Omega-3 Fatty Acids (EPA + DHA)

  • Why: Reduce pro-inflammatory cytokines, support myelin repair, calm immune response
  • Dose: 2000–4000 mg/day
  • Best Form: Triglyceride fish oil, krill oil, or algae oil

2. Vitamin D3 + K2

  • Why: Modulates immune system, reduces MS risk and relapses
  • Dose: 4000–6000 IU/day D3 + 100–200 mcg K2
  • Tip: Aim for 40–70 ng/mL of 25(OH)D

3. Curcumin (Turmeric Extract)

  • Why: Potent anti-inflammatory and antioxidant
  • Form: Bioavailable formulas (Meriva®, Theracurmin®, BCM-95®)
  • Dose: 500–1000 mg/day

4. Alpha-Lipoic Acid (ALA)

  • Why: Reduces oxidative stress, protects nerves, improves mobility
  • Dose: 600–1200 mg/day
  • Note: Also supports blood-brain barrier integrity

5. Probiotics + Prebiotics

  • Why: Reduce gut-driven inflammation and autoimmunity
  • Top strains: Lactobacillus rhamnosus, Bifidobacterium infantis, L. plantarum
  • Add in: Prebiotic fibers (inulin, FOS, GOS, resistant starch)

6. Magnesium (Glycinate or Malate)

  • Why: Calms nerves, relaxes muscles, counters inflammation
  • Dose: 300–500 mg/day

7. CoQ10

  • Why: Supports mitochondrial function and cellular energy
  • Bonus: Reduces oxidative stress linked to inflammation

Looking for supplements for people with MS? Click here.

🛌 Step 3: Optimize Sleep and Recovery

Chronic inflammation is fueled by poor sleep, which is common in MS.

Tips for deeper, restorative sleep:

  • Magnesium glycinate or threonate before bed
  • Herbal support like valerian root, passionflower, or CBD
  • Block blue light after sunset
  • Keep a cool, dark sleep environment
  • Go to bed at the same time every night

😴 Aim for 7–9 hours of quality sleep, not just time in bed.

🧘 Step 4: Manage Stress with Nervous System Support

Stress is a major driver of MS inflammation via the HPA axis. Long-term, chronic stress dysregulates cortisol and can worsen relapses.

Strategies to lower inflammation via stress reduction:

  • Breathwork or vagus nerve stimulation
  • Mindfulness meditation or guided imagery
  • Adaptogenic herbs like Ashwagandha, Rhodiola, or Bacopa
  • Nature exposure (walking in greenery lowers cortisol)
  • Journaling or emotional release practices

🌿 Supporting your nervous system reduces inflammatory signaling at the root.

🏃 Step 5: Move Every Day—Even Gently

Exercise may seem hard when fatigue or stiffness hits, but regular gentle movement reduces inflammation and boosts mitochondrial health.

Ideal anti-inflammatory activities for MS:

  • Walking or rebounding
  • Swimming or aquatic exercise
  • Resistance bands or bodyweight training. Want to train at home? Click here.
  • Tai chi, yoga, or Pilates
  • Stretching + foam rolling

💡 Even 10–15 minutes a day makes a difference.

🧬 Bonus: Natural Anti-Inflammatory Stacks

Here are sample combos based on your main symptoms:

Goal Supplement Stack
Brain fog + fatigue Omega-3 + CoQ10 + Curcumin + Magnesium Threonate
Muscle tightness Magnesium Malate + Vitamin D3 + ALA
Gut-driven inflammation Probiotic + L-Glutamine + Curcumin
Immune balance Vitamin D3/K2 + Omega-3 + Mushroom blends (Reishi, Lion’s Mane)
Nerve pain ALA + Magnesium + CBD or Valerian Root

📋 What to Watch Out For

  • Always consult your neurologist before adding new supplements—especially if you're on DMTs
  • Start one at a time, not all at once
  • Use only third-party tested brands
  • Avoid unnecessary fillers or mega-doses unless prescribed
  • Track your response (energy, mobility, pain, mood, sleep)

💬 Real MS Voices

“Switching to a Wahls-style diet cut my flare-ups in half. I also use turmeric and magnesium every day.”
Leah, 41, RRMS

“I started high-dose Omega-3 and noticed less stiffness in 2 weeks. It was subtle but real.”
Marcus, 37, SPMS

“My biggest win came when I focused on gut health with probiotics and bone broth. It lowered my brain fog a lot.”
Sandra, 52, PPMS

🧠 Final Thoughts: You Can Influence Your Inflammation

MS may be unpredictable, but you’re not powerless when it comes to inflammation. Every food choice, every breath, every night of rest—each one can shift your internal chemistry toward healing.

Here’s what matters most:

  • Eat whole, anti-inflammatory foods
  • Take targeted supplements (omega-3s, D3, magnesium, probiotics)
  • Move, sleep, and decompress regularly
  • Build a long-term wellness plan—not a quick fix

Your body already knows how to heal. Your job is to give it what it needs—and remove what stands in its way.

Looking for supplements for people with MS? Click here.

Back to blog